BCR (Breakpoint Cluster Region) Detection in Blood by Qualitative PCR
This test checks for the presence of a genetic abnormality involving the BCR and ABL genes, commonly linked to certain blood cancers like chronic myeloid leukemia (CML).
["Assesses for a genetic marker tied to specific blood disorders that may require targeted treatment."]
Key facts at a glance
- LOINC
- 46434-7
- Short code
- t(9;22)(ABL1,BCR)/control Bld/T
- Synonyms
- t(9;22)(ABL1,BCR)/control Bld/T
- Category
- coagulation
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have symptoms of blood cancer, such as unexplained fatigue, weight loss, or swollen lymph nodes. It’s also used to monitor treatment progress in patients already diagnosed with certain blood disorders.
What to Expect Before the Test
No special preparation is needed. A small blood sample is drawn from a vein, usually in your arm. The process is quick and typically done in a clinic or lab setting.
How the Results Are Interpreted
Results are qualitative (yes/no) and indicate whether the BCR/ABL gene rearrangement is present. Positive results suggest the presence of the genetic abnormality linked to the condition being tested.
What the Results Mean
Positive results may confirm a diagnosis of certain blood cancers or monitor treatment effectiveness. Negative results mean the genetic marker is not detected in this sample.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is critical for diagnosing chronic myeloid leukemia (CML) and guiding treatment decisions. It helps determine if the cancer is responding to therapy by detecting the BCR/ABL fusion gene, which drives the disease. Regular monitoring with this test ensures timely adjustments to treatment plans.
Short name
BCR/ABL Test (Qualitative PCR)
Frequently asked questions
What does a positive result mean?
Can this test be done on other body fluids?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy