BCR/ABL Fusion Gene Detection by Qualitative PCR (Blood)
This test checks for the presence of a genetic fusion between the BCR and ABL genes, which is linked to chronic myeloid leukemia (CML). It helps monitor whether your treatment is working and if the disease is in remission.
["This test helps track leukemia progression and treatment response in chronic myeloid leukemia (CML)."]
Key facts at a glance
- LOINC
- 21822-2
- Short code
- t(9;22)(ABL1,BCR) Major Bld/T Ql
- Synonyms
- t(9;22)(ABL1,BCR) Major Bld/T Ql
- Category
- coagulation
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have chronic myeloid leukemia (CML) or are being treated for it. It’s also used to check if the disease is responding to therapy or if it has returned. This test is typically done during follow-up visits to ensure your treatment plan remains effective.
How the Test Works
Blood is collected and analyzed for the BCR-ABL fusion gene using a special type of PCR (polymerase chain reaction) test. This test detects the genetic material that causes CML by identifying the specific combination of genes that have fused together. The result tells whether the fusion is present in your blood cells.
What to Expect Before the Test
There are no special preparations needed for this test. You may have a small needle inserted into your arm to draw blood, similar to other blood tests. You can eat and drink normally before the test.
What to Expect During the Test
The blood sample is processed in a lab to detect the BCR-ABL fusion gene. Results are usually available within a few days, depending on lab processing times. Your doctor will discuss the results with you.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is critical for managing chronic myeloid leukemia. A positive result confirms the presence of the disease, while a negative result after treatment suggests remission. Regular monitoring with this test helps doctors adjust treatment plans to prevent relapse. It’s also useful for assessing how well your body is responding to therapies like tyrosine kinase inhibitors.
Short name
BCR-ABL Status Check
Frequently asked questions
How long does it take to get the results of this test?
What does a positive result mean?
Can lifestyle changes affect this test result?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy