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B-cell receptor (BCR) gene rearrangement analysis (for B-cell lymphoma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for changes in the genetic material of B-cells, which may help diagnose or monitor certain blood cancers like lymphoma.

Quick summary

["Assists in identifying genetic mutations linked to B-cell cancers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
21795-0
Short code
t(9;22)(ABL1,BCR) NFr Bld/T
Synonyms
t(9;22)(ABL1,BCR) NFr Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms of lymphoma (such as swollen lymph nodes, fatigue, or unexplained weight loss) or if you’re at higher risk due to family history or exposure to certain factors. It helps determine if cancer cells have rearranged the B-cell receptor genes, which can guide treatment decisions.

How the Test Works

A small sample of blood is taken, and the genetic material (DNA) from your white blood cells is examined for specific rearrangements in the BCR genes. Advanced laboratory techniques identify these changes, which are unique to certain types of B-cell cancers.

Sample Collection

Whole blood is collected in a special tube and sent to a lab. The test focuses on the DNA from your immune cells, not the blood plasma or other fluids.

What to Expect Before the Test

No special preparation is needed. You may experience mild discomfort from the needle, but it’s a quick process similar to a routine blood draw.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a key role in diagnosing and classifying B-cell lymphoma by identifying genetic mutations that distinguish cancerous B-cells from healthy ones. Results help determine the most effective treatment plan, including targeted therapies or chemotherapy, by confirming the presence of specific genetic rearrangements.

Short name

BCR Rearrangement Test

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of genetic rearrangements in B-cell receptors, strongly suggesting B-cell lymphoma or another related blood disorder. This finding helps your healthcare team tailor treatment options.
How long does it take to get results?
Results typically take several weeks, as this is a complex genetic analysis. Your doctor will discuss the findings once available.
Is this test covered by insurance?
Check with your insurance provider to confirm coverage, as genetic testing can vary in cost and reimbursement depending on your plan and diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy