BRCA2 Mutation Status (Serum/Plasma Probe Screening)
This test checks for genetic changes in the BRCA2 gene, which may increase your risk of certain cancers like breast or ovarian cancer. It uses a blood sample to detect specific DNA sequences associated with hereditary cancer syndromes.
["A BRCA2 mutation screening test helps identify if you may have a higher risk for inherited cancer, guiding future prevention or monitoring strategies."]
Key facts at a glance
- LOINC
- 52130-2
- Short code
- t(ABL1,BCR)b2a2/control Bld/T
- Synonyms
- t(ABL1,BCR)b2a2/control Bld/T
- Category
- coagulation
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of breast, ovarian, prostate, or pancreatic cancer, or if you were diagnosed with certain cancers at a younger age. It may also be suggested if you have a known BRCA1 or BRCA2 mutation in your family.
How the Test Works
A small blood sample is taken from your arm. The DNA from your blood cells is analyzed to look for specific mutations in the BRCA2 gene using a sensitive DNA probe technique. This helps determine if you carry any harmful genetic variations linked to cancer risk.
What to Expect Before the Test
No special preparation is needed for this test. You may have some mild discomfort from the needle, but it usually goes away quickly. If you are pregnant or breastfeeding, let your healthcare provider know before the test.
What to Expect After the Test
After the blood sample is taken, you can return to your normal activities immediately. You may experience slight bruising or swelling at the puncture site, which typically resolves within a few days. Avoid heavy lifting or strenuous activities for the rest of the day if needed.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Having a BRCA2 mutation means you are at a higher risk for certain cancers, including breast, ovarian, pancreatic, and prostate cancer. If a mutation is found, your healthcare provider will discuss personalized cancer prevention strategies, such as increased cancer screenings, medications, or surgery, to help manage your risk.
Short name
BRCA2 Mutation Screen
Frequently asked questions
What does a positive result mean?
Can I still get cancer even if I have a BRCA2 mutation?
How often will I need follow-up tests if I have a positive result?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy