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Total Bilirubin, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin in your blood. Bilirubin is a yellow pigment produced when red blood cells break down, and it helps your liver process waste products.

Quick summary

["Your liver’s ability to process bilirubin may be affected by conditions like liver disease or bile duct blockages."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
69963-7
Short code
t(ABL1,BCR)e1a2/control Mar
Synonyms
t(ABL1,BCR)e1a2/control Mar
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Bilirubin is normally processed by your liver and excreted through bile into your intestines. If your liver isn’t working properly, bilirubin can build up in your blood, leading to jaundice (yellowing of the skin and eyes). This test helps doctors check for liver issues or other problems that may affect bilirubin levels.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm to draw a blood sample. If you’re nervous, let your healthcare provider know—they can help make it more comfortable.

What the Results Mean

Higher than normal bilirubin levels can indicate liver disease, bile duct problems, or conditions like hemolytic anemia (where red blood cells break down too quickly). Lower levels might suggest liver damage or certain medications affecting bilirubin processing.

Common Conditions Linked to Bilirubin Levels

Elevated bilirubin is often seen in conditions like hepatitis, cirrhosis, gallstones, or blockages in the bile ducts. It can also appear in newborns (jaundice) or in people with hemolytic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated bilirubin can cause symptoms like jaundice (yellow skin/eyes), dark urine, or pale stools. Low levels may not cause noticeable symptoms but could signal underlying liver or metabolic issues that need further evaluation.

Short name

Total Bilirubin

Frequently asked questions

What causes bilirubin to build up in my blood?
Bilirubin builds up when your liver struggles to process it properly, often due to liver disease, bile duct blockages, or conditions that increase red blood cell breakdown (like anemia).
How long does it take to get my bilirubin test results?
Results are typically available within 1–3 business days, depending on your lab. Your healthcare provider will discuss them with you.
Can I eat or drink before this test?
No special diet is needed, but avoid alcohol or heavy meals 24 hours before your appointment to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy