Tacrolimus blood mass concentration
This test measures the amount of tacrolimus, a medication used to prevent organ rejection after a transplant, in your blood.
["Tacrolimus levels help doctors monitor your dose to avoid side effects or rejection."]
Key facts at a glance
- LOINC
- 74096-9
- Short code
- Tacrolimus Bld IA-mCnc
- Synonyms
- Tacrolimus Bld IA-mCnc
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
This test is done to measure the amount of tacrolimus, an immunosuppressant medicine, in your blood so your care team can be sure your dose is high enough to help protect your transplanted organ from rejection while staying low enough to limit the risk of side effects.
Your healthcare provider may order this test if you’re on tacrolimus to manage a transplant or a condition requiring immunosuppression. It helps ensure the medication is at the right level to protect your body without causing too much suppression of your immune system.
Your result shows whether the level of tacrolimus in your blood falls within the target range your care team has set for you. A level that is too low may not protect your transplant from rejection, while a level that is too high can raise the chance of side effects such as kidney problems or infections.
Results are not provided with specific numeric ranges here. Your doctor will interpret the result in relation to your treatment plan and symptoms. Low levels may indicate the medication isn’t working effectively, while very high levels could signal overdose or toxicity.
The sample is collected during a routine blood draw, usually from a vein on the inside of your elbow or the back of your hand. A trained staff member will clean your skin, insert a small needle, and collect one or more tubes of blood, which usually takes only a few minutes.
A blood sample is taken from a vein, usually in your arm, by a healthcare professional. You may feel a small pinch, but it usually doesn’t cause discomfort afterward.
Many care teams ask you to have your blood drawn in the morning just before you take your tacrolimus dose, because this trough level shows the lowest amount of medicine in your body. Tell your provider about every medicine and supplement you use, and follow any other instructions you are given.
Follow your doctor’s instructions carefully. Avoid taking any medications (including over-the-counter drugs) without approval, as they can affect test results. Also, inform your provider if you’re pregnant, breastfeeding, or have allergies.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Tacrolimus Level
Frequently asked questions
Tacrolimus is a critical medication for transplant patients to prevent organ rejection. Monitoring levels ensures the dose is optimized to balance immune suppression and safety. Abnormal levels can lead to complications like infections, organ rejection, or toxicity, requiring immediate medical attention.
Your doctor will determine the frequency based on your treatment plan, but it may be done weekly or monthly, especially during the early stages of your medication regimen.
If your level is too low, your body may not be receiving enough medication to prevent rejection. Your doctor might adjust your dose or prescribe an additional medication to help.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy