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Tacrolimus concentration in plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of tacrolimus, a medication used to prevent organ rejection after a transplant, in your blood plasma.

Quick summary

["Tacrolimus levels help ensure your dose is safe and effective for managing transplant rejection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72945-9
Short code
Tacrolimus (neut) IgM SerPl Ql FC
Synonyms
Tacrolimus (neut) IgM SerPl Ql FC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to monitor your tacrolimus levels, especially if you’re taking this medication to prevent your body from rejecting a transplanted organ (e.g., heart, liver, or kidney). Proper dosing is critical to avoid side effects like high blood pressure, infections, or organ damage.

What to Expect Before the Test

No special preparation is usually needed. You may have a small needle inserted into a vein (venipuncture) in your arm. The test involves drawing a small amount of blood, which typically takes a few minutes. If you’re on a transplant regimen, your provider may schedule this test regularly.

What the Results Mean

Results help your doctor adjust your medication to keep levels within a target range. Too little tacrolimus may not prevent rejection, while too much can cause harmful side effects. Your doctor will discuss these results with you and adjust your treatment plan as needed.

Common Side Effects to Watch For

While rare, high tacrolimus levels can cause symptoms like nausea, headaches, or tremors. If you experience unusual fatigue, vision changes, or signs of infection (e.g., fever, sore throat), contact your healthcare provider immediately.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Tacrolimus levels are crucial for transplant patients because they directly impact organ survival and your overall health. Blood tests are used to balance the risk of rejection versus side effects, ensuring long-term stability.

Short name

Tacrolimus Level

Frequently asked questions

Why do I need this test regularly if I’m on tacrolimus?
Regular testing helps your doctor monitor your medication levels to prevent both rejection of the transplanted organ and dangerous side effects. Tacrolimus works differently in each person, so frequent checks ensure your dose stays optimal.
What happens if my tacrolimus level is too high?
High levels may cause symptoms like nausea, high blood pressure, or kidney problems. Your doctor will adjust your dose to bring it back into the safe range, possibly by reducing your medication temporarily or switching to a different regimen.
Can I eat or drink anything before this test?
You can eat and drink normally unless your doctor specifies otherwise. No fasting is required for this blood test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy