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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help your body stay healthy by maintaining fluid balance and supporting immune function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30160-6
Short code
Tau Prot CSF-mCnc
Synonyms
Tau Prot CSF-mCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if they suspect conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help monitor chronic conditions like heart failure or certain autoimmune diseases.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Higher-than-normal protein levels might indicate conditions like multiple myeloma or severe dehydration. Lower-than-normal levels could suggest malnutrition, liver disease, or kidney problems. Your results will be compared to standard ranges for your age and health status.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions such as kidney disease (e.g., nephrotic syndrome), liver disorders, or chronic infections. It can also help assess protein-losing gastrointestinal diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes protein levels to be too high?
High protein levels can result from conditions like multiple myeloma (a cancer of plasma cells), severe dehydration, or certain kidney diseases. Overproduction of specific proteins (e.g., monoclonal gammopathy) may also lead to elevated total protein. Your healthcare provider will review your medical history and other test results to determine the cause.
What causes protein levels to be too low?
Low protein levels are often due to liver disease (e.g., cirrhosis), kidney disease (e.g., nephrotic syndrome), malnutrition, or chronic infections. Certain medications or conditions that affect protein synthesis or absorption in the gut can also contribute. If you notice unexplained weight loss, fatigue, or swelling, discuss these symptoms with your provider.
How often should I get this test?
The frequency of this test depends on your health condition and treatment plan. If you have a chronic condition like kidney disease or liver disease, your provider may recommend regular monitoring. For routine check-ups or specific symptoms, they may order it less often, such as every few years or as needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy