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Tbevigmtitrcsfia

Published: August 9, 2026Updated: August 16, 2026

This test detects IgM antibodies against tick-borne encephalitis virus in cerebrospinal fluid to help diagnose viral infection affecting the brain and spinal cord.

Quick summary

{"Detects IgM antibodies in cerebrospinal fluid indicating recent infection","Helps diagnose tick-borne encephalitis, a viral brain infection","Sample is collected via lumbar puncture (spinal tap)","Positive result suggests current or recent TBEV infection","Transmitted through tick bites, common in parts of Europe and Asia"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104397-5
Short code
TBEV IgM CSF
Synonyms
TBEV IgM Titr CSF IA
Category
cardiac
Sample
csf
Container
Sterile CSF collection container (polypropylene or glass tube)
Units
N/A
Ref low
0
Ref high
10
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Immunoassay
CPT
86635
SNOMED
122442009
Specimen volume
1-2 mL of cerebrospinal fluid
Stability
Refrigerated (2-8°C): up to 72 hours. Frozen (-20°C or below): up to 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
200
TAT
24–72 hours
Order
routine

What is this test?

The European tick-borne encephalitis virus IgM antibody test is a laboratory test performed on cerebrospinal fluid (CSF), the clear fluid surrounding your brain and spinal cord. It detects IgM antibodies that your immune system produces in response to the tick-borne encephalitis virus (TBEV). This test uses immunoassay techniques to identify whether these specific antibodies are present, helping doctors determine if you have a current or recent infection affecting your central nervous system.

How is the sample collected?

Cerebrospinal fluid is collected through a procedure called a lumbar puncture, commonly known as a spinal tap. During this procedure, a healthcare provider inserts a thin needle between the bones (vertebrae) in your lower back to withdraw a small amount of CSF. The fluid is then sent to a laboratory for analysis. This method allows direct detection of antibodies in the fluid that surrounds the brain and spinal cord, which is particularly important for diagnosing neurological infections.

Why might I need this test?

Your doctor may order this test if you have symptoms of tick-borne encephalitis, especially if you have been in areas where TBE is common (such as parts of Central, Eastern, and Northern Europe and northern Asia). Symptoms typically include fever, headache, fatigue, muscle aches, and in more severe cases, meningitis (inflammation of the membranes surrounding the brain) or encephalitis (inflammation of the brain). The test is particularly important when symptoms suggest the infection has spread to the central nervous system.

Reference range

Negative: < 1:10 titer or No detectable IgM antibodies detected. Positive: >= 1:10 titer or Detectable IgM antibodies (indicates acute or recent infection). Borderline: 1:5 to 1:10 titer (recommend repeat testing)N/A

Specimen: csf

No special preparation required. Patient should inform healthcare provider of any recent infections, tick bites, or travel to endemic areas. Standard CSF collection procedure applies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is tick-borne encephalitis the same as Lyme disease?
No, these are different diseases. Tick-borne encephalitis is caused by a virus (TBEV), while Lyme disease is caused by bacteria (Borrelia burgdorferi). They are transmitted by different species of ticks and cause different symptoms. TBE affects the nervous system more directly, while Lyme disease often starts with a characteristic rash and can affect joints, skin, and nervous system if untreated.
How long does it take to get results?
Results are typically available within several days to a week, depending on the laboratory. The test involves specialized immunoassay techniques that require specific equipment and expertise, so it is usually performed at reference laboratories.
Can the test be done on blood instead of CSF?
While blood tests can detect TBEV antibodies, testing CSF is more specific for diagnosing neurological involvement. The CSF test directly shows whether the virus has reached the central nervous system, which is important for proper diagnosis and treatment planning.
Is vaccination available for tick-borne encephalitis?
Yes, effective vaccines are available and widely used in endemic areas. The vaccination is recommended for people who live in or travel to regions where TBE is common. However, vaccination does not affect this diagnostic test, as the test detects antibodies from natural infection, not from vaccination.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy