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Serum Total Cholesterol (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of cholesterol in your blood serum. Cholesterol is a type of fat that your body needs for healthy cells, but having too much can increase your risk of heart disease.

Quick summary

["Your cholesterol levels help assess heart health and risk of cardiovascular disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13276-1
Short code
T canis IgA Ser-aCnc
Synonyms
T canis IgA Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Cholesterol is an essential component of cell membranes and a precursor to hormones and vitamin D. However, high cholesterol levels can lead to plaque buildup in your arteries, increasing the risk of heart attack or stroke. This test helps doctors monitor your overall cholesterol status and guide treatment plans if needed.

What to Expect Before the Test

No special preparation is usually required, but you may be asked to fast for 9–12 hours before the test if your doctor recommends it. This helps ensure accurate results. Bring any medications you’re currently taking, as some may affect cholesterol levels.

How the Test Is Performed

A healthcare professional will draw blood from a vein in your arm using a small needle. The blood sample is then sent to a lab for analysis. The test measures the total cholesterol, which includes both low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, as well as triglycerides.

What the Results Mean

Results are typically reported as a single number (total cholesterol) rather than individual components. While exact reference ranges vary by lab, higher-than-normal levels may signal a need for lifestyle changes, diet adjustments, or medical interventions to manage cardiovascular risk.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Cholesterol

Frequently asked questions

What causes cholesterol levels to change?
Several factors influence cholesterol levels, including diet (e.g., high intake of saturated or trans fats), genetics, weight, physical activity, and certain medications. Lifestyle choices like smoking, alcohol consumption, and stress also play a role.
How often should I get this test?
Your doctor will determine how frequently you need cholesterol testing based on your age, risk factors (e.g., family history of heart disease, high blood pressure), and overall health. Typically, adults with no risk factors may get tested every 4–6 years, while those at higher risk may need more frequent checks.
Can diet or exercise affect my cholesterol results?
Yes! Adopting a heart-healthy diet (rich in fruits, vegetables, whole grains, and lean proteins) and increasing physical activity can lower LDL cholesterol and raise HDL cholesterol. Small, sustainable changes often yield the best long-term results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy