T-cell receptor beta chain gene rearrangement (T-cell receptor beta diversity)
This test analyzes the genetic rearrangement patterns of T-cell receptor beta genes in your blood or bone marrow. It helps assess whether your immune system’s T-cells are developing normally, often used in diagnosing or monitoring conditions like lymphoma, leukemia, or immune deficiencies.
["This test evaluates T-cell genetic diversity, useful for diagnosing or tracking immune-related diseases."]
Key facts at a glance
- LOINC
- 60581-6
- Short code
- TCRB gene Rear Fld Ql
- Synonyms
- TCRB gene Rear Fld Ql
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- CPT
- 86430
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Doctors may order this test to investigate unexplained immune system issues, such as chronic infections, autoimmune diseases, or cancers like lymphoma or leukemia. It can also help determine if a bone marrow transplant is suitable by checking T-cell development.
What Does the Test Measure?
The test looks at how T-cells’ beta genes rearrange during development. Healthy immune systems typically show a diverse range of rearrangements, while certain diseases may show limited or abnormal patterns.
Sample Collection and Preparation
A blood sample (whole blood) or bone marrow sample is usually collected. The lab processes the sample to isolate T-cells and analyze their genetic rearrangements using advanced molecular techniques.
What Are Possible Results?
Results may show normal diversity, restricted diversity (indicating potential disease), or other patterns that help guide further medical evaluation. Exact interpretations depend on clinical context and comparison to known disease-specific profiles.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal T-cell receptor beta diversity can signal underlying immune disorders, such as T-cell lymphomas, severe combined immunodeficiency (SCID), or other congenital immune deficiencies. It may also help monitor treatment response in cancer or autoimmune conditions.
Short name
T-cell receptor beta diversity (TβRD)
Frequently asked questions
What does a normal result mean?
Can this test detect all types of T-cell cancers?
How long does it take to get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy