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T-cell receptor rearrangement analysis (blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic rearrangements in T-cells, which can help identify conditions like certain cancers or immune disorders.

Quick summary

This test helps doctors diagnose or monitor immune-related conditions by examining DNA changes in T-cells.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101637-7
Short code
TCRB & TCRG gene rearrange Bld/T
Synonyms
TCRB & TCRG gene rearrange Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test analyzes DNA sequences from T-cells to detect specific rearrangements in their gene segments. These rearrangements are natural during immune development but can be abnormal in conditions such as lymphoma or other hematologic malignancies.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms of a blood disorder, such as persistent lymphadenopathy (swollen lymph nodes), unexplained weight loss, or other signs of a possible immune or cancerous condition. It’s also used in research or specialized diagnostic settings.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The sample is processed to isolate T-cells, whose DNA is then analyzed for rearrangement patterns. This process may take several days for detailed results.

Common Conditions Monitored

This test is primarily used in research or specialized clinical settings to investigate rare or complex immune disorders, including certain types of lymphoma or leukemia. It may also be part of a broader diagnostic workup for unexplained immune system abnormalities.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test helps identify genetic changes in T-cells that may indicate underlying immune disorders or malignancies. While not routinely used in standard clinical practice, it plays a critical role in research and highly specialized diagnostics. Results may guide treatment decisions in specific cases, such as precision oncology or rare disease management.

Short name

T-cell receptor rearrangement test

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of abnormal T-cell rearrangements, which may suggest conditions like certain lymphomas or other hematologic malignancies. However, further evaluation and clinical correlation are necessary to determine the exact cause and next steps.
How long will it take to get results?
Results may take several days to weeks, depending on the laboratory’s workflow and complexity of the analysis. Your healthcare provider will discuss the timeline with you during your appointment.
Is this test covered by insurance?
Coverage depends on your insurance plan, the clinical indication, and whether the test is part of a broader diagnostic workup. Always confirm with your insurance provider or healthcare team before scheduling the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy