T-cell receptor rearrangement study (Genetic Analysis)
This test checks for unique genetic patterns in your T-cells, which may help identify immune-related conditions or monitor treatments for certain cancers or autoimmune diseases.
Assists in diagnosing and managing immune system disorders by analyzing T-cell genetic sequences.
Key facts at a glance
- LOINC
- 101636-9
- Short code
- TCRB & TCRG gene rearrange Mar
- Synonyms
- TCRB & TCRG gene rearrange Mar
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test examines the genetic rearrangement of T-cell receptors (TCRs) in your blood or bone marrow. TCRs are proteins on T-cells that help your immune system recognize and respond to foreign invaders. This analysis looks for specific patterns of DNA sequences that may indicate abnormal immune activity, such as in certain cancers or autoimmune diseases.
Why It’s Ordered
Your healthcare provider may recommend this test if you have symptoms or a history suggestive of conditions like chronic lymphocytic leukemia (CLL), T-cell lymphoma, or other immune-related disorders. It can also be used to monitor treatment responses in patients undergoing immunotherapy.
Sample Collection and Preparation
A blood sample is typically taken from a vein in your arm. If the test involves bone marrow, a small sample may be taken from your hip bone under sterile conditions. The sample is then sent to a lab for genetic analysis.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to avoid certain medications or supplements that could interfere with results. If you have a bone marrow biopsy, your provider will explain the process and any potential risks.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test plays a critical role in diagnosing and managing diseases involving abnormal T-cell activity. For example, it can confirm the presence of T-cell lymphoma or chronic lymphocytic leukemia by identifying characteristic genetic rearrangements. Additionally, it helps tailor treatment plans, such as determining the most effective therapies for patients with immune-related cancers or autoimmune conditions.
Short name
T-cell Receptor (TCR) Rearrangement Test
Frequently asked questions
What does a positive or abnormal result mean?
Will I need additional tests if this result is abnormal?
Can lifestyle or diet affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy