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T-cell receptor rearrangement analysis (Genomic DNA)

Published: August 9, 2026Updated: August 16, 2026

This test checks for unique genetic patterns in your white blood cells’ DNA to identify if certain T-cells have been altered, which can help diagnose conditions like lymphoma or other immune-related disorders.

Quick summary

["This test helps doctors understand if abnormal T-cell activity is present in your blood or tissues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101638-5
Short code
TCRB & TCRG gene rearrange Spec
Synonyms
TCRB & TCRG gene rearrange Spec
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms like unexplained weight loss, night sweats, persistent fatigue, or swollen lymph nodes. It’s also used in research or when other tests suggest possible immune system issues.

What to Expect Before the Test

You’ll provide a blood sample (whole blood) collected by a healthcare professional. The sample is processed to extract DNA from your white blood cells. No special preparation is needed, but inform your doctor about any medications you’re taking.

How the Test Works

The DNA is analyzed for specific rearrangements in the T-cell receptor genes. These rearrangements occur naturally but can be abnormal in certain diseases, helping identify unique genetic signatures.

Possible Results and Next Steps

Results may show normal patterns, abnormal rearrangements, or no detectable changes. If abnormalities are found, further testing or a biopsy may be needed to determine the cause, such as a type of lymphoma or autoimmune condition.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

T-cell receptor (TCR) Rearrangement Test

Frequently asked questions

What does this test measure?
This test measures genetic rearrangements in T-cell receptor genes found in white blood cells. It detects whether these genes have been altered in a way that may indicate an immune disorder or cancer.
What does it mean if my results are abnormal?
Abnormal results may suggest conditions like non-Hodgkin lymphoma, certain autoimmune diseases, or other immune-related disorders. Your doctor will discuss these findings with you and may recommend additional tests or treatments.
How long will I need to wait for results?
Results typically take several weeks to a few months, depending on the complexity of the analysis and laboratory processes. Your healthcare provider will contact you once results are ready.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy