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Alpha-1 Antitrypsin (Serum) Activity

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of Alpha-1 Antitrypsin, a protein that helps protect your lungs and liver from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps prevent lung and liver damage; low levels may indicate genetic disorders or chronic inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73123-2
Short code
Terazosin ind plt IgG SerPl Ql FC
Synonyms
Terazosin ind plt IgG SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of lung diseases (such as chronic obstructive pulmonary disease or emphysema), liver problems, or if you have a family history of Alpha-1 Antitrypsin deficiency. It can also be used to monitor treatment progress or screen for genetic conditions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re concerned about needles or blood draws, let your healthcare provider know.

What the Test Results Mean

Results help determine if your Alpha-1 Antitrypsin levels are within normal ranges or if they are low, which could suggest a genetic disorder or other health concerns. Your provider will discuss the results with you in detail.

Common Conditions Monitored

This test is particularly important for diagnosing or managing Alpha-1 Antitrypsin deficiency, a genetic disorder that increases the risk of lung diseases and liver problems. It may also be used in research or specialized care plans.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin Activity

Frequently asked questions

What does a low Alpha-1 Antitrypsin level mean?
A low level may indicate Alpha-1 Antitrypsin deficiency, which can lead to lung diseases like emphysema or liver cirrhosis. Your provider will assess your symptoms and medical history to guide further action.
Can diet or supplements affect this test?
Dietary changes or supplements may not directly affect Alpha-1 Antitrypsin activity levels, but certain medications (like steroids) can influence inflammation-related proteins. Always follow your provider’s advice.
How often should this test be repeated?
Frequency depends on your condition. If you have a known deficiency, your provider may recommend regular monitoring. If this is a screening test, they may check results once or as needed based on your health status.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy