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Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and compares albumin to globulin proteins to help assess protein balance and potential health issues.

Quick summary

["Understanding protein balance can reveal hidden kidney, liver, or immune system problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
89599-5
Short code
T gondii CSF Ql Cult
Synonyms
T gondii CSF Ql Cult
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
organism-specific-culture
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein includes albumin and globulin, both vital for transporting nutrients, maintaining fluid balance, and supporting immunity. Low levels may signal malnutrition, liver/kidney disease, or excessive protein loss (e.g., from wounds or kidney disorders).

Why Is the Albumin-to-Globulin Ratio Important?

This ratio helps distinguish between conditions affecting albumin (e.g., liver disease) versus globulin (e.g., chronic inflammation or immune disorders). A higher globulin-to-albumin ratio may indicate immune activation or chronic illness.

How Is This Test Performed?

A blood sample is drawn, and lab tests measure total protein content and separately evaluates albumin and globulin fractions using standard protein electrophoresis or immunoassay methods.

Common Conditions Monitored

This test is often used to screen for malnutrition, chronic liver disease, kidney dysfunction, or autoimmune conditions. It may also guide treatment for conditions like nephrotic syndrome or inflammatory diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein + A:G Ratio

Frequently asked questions

Will I need to prepare for this test?
No special preparation is needed, but avoid heavy meals 2 hours before your blood draw for more accurate results.
What are typical reference ranges?
Reference ranges vary by lab, but total protein is often reported as 6.4–8.3 g/dL, with albumin 3.5–5.0 g/dL and globulin 2.0–4.0 g/dL. Your doctor will interpret these values with your overall health.
Can diet affect my protein test results?
Yes; high-protein diets may temporarily raise total protein levels, while malnutrition can lower them. Your doctor may ask about recent diet changes if results seem unexpected.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy