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Tissue Transglutaminase Antibody (IgA) – Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies against tissue transglutaminase, a protein involved in gluten-related intestinal damage. It helps diagnose celiac disease, an autoimmune condition triggered by gluten.

Quick summary

["This test may help identify celiac disease by detecting harmful antibodies linked to gluten sensitivity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42626-2
Short code
T gondii DNA CSF Ql NAA+probe
Synonyms
T gondii DNA CSF Ql NAA+probe
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may recommend this test if you have symptoms like persistent diarrhea, abdominal pain, weight loss, or fatigue, especially if you’ve been diagnosed with gluten sensitivity or have a family history of celiac disease. It’s also used to confirm a diagnosis when other tests or symptoms suggest gluten-related damage.

What Does a Positive Result Mean?

A positive result strongly suggests celiac disease, as it indicates the body’s immune system is attacking the small intestine due to gluten exposure. This means you may need to follow a strict gluten-free diet to prevent long-term damage.

What Does a Negative Result Mean?

A negative result means your body did not detect these antibodies, which could mean you don’t have celiac disease at this time. However, false negatives can occur, so further testing or a gluten challenge may be needed to confirm.

How Is This Test Performed?

A small blood sample is drawn from your arm. The sample is tested using an immunoassay method to detect the presence of IgA anti-tissue transglutaminase antibodies. Results are typically available within 24–48 hours.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Celiac Disease and Gluten Sensitivity

Short name

IgA Anti-TTG Antibody

Frequently asked questions

What are the symptoms of celiac disease?
Symptoms can vary widely but often include digestive issues like chronic diarrhea or bloating, unexplained weight loss, fatigue, or a failure to thrive in children. Non-digestive symptoms may include skin rashes, anemia, or joint pain. Some people may also experience delayed growth or developmental delays in children.
How does gluten affect the body in celiac disease?
In celiac disease, gluten triggers an immune response that damages the small intestine’s lining, leading to malabsorption of nutrients. This can cause long-term health problems if untreated, including nutrient deficiencies, osteoporosis, or an increased risk of certain cancers.
Can celiac disease be treated?
Yes, celiac disease is managed through a strict gluten-free diet, which removes all wheat, barley, rye, and cross-contaminated ingredients. This can help restore intestinal health and prevent complications. Regular monitoring with a healthcare provider is important to ensure proper nutrition and address any complications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy