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Total Protein with Albumin and Globulin Profile (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels in your blood, along with the amounts of albumin and globulin proteins, which help support your body’s immune function and fluid balance.

Quick summary

["Understanding your protein balance can help identify issues like malnutrition, liver disease, or immune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109719-5
Short code
T gondii DNA Msmt CSF
Synonyms
T gondii DNA Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test to check for conditions affecting protein production or breakdown, such as kidney disease, liver problems, or certain infections. It can also help monitor long-term conditions like heart failure or malnutrition.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if albumin is specifically measured. Bring any medications you’re taking to your doctor’s office.

How the Test Works

A small blood sample is drawn from a vein in your arm. The blood is then analyzed to separate and measure total protein, albumin, and globulin levels using standard laboratory techniques.

What the Results Mean

Results show whether your protein levels are too high or too low. High total protein may indicate dehydration or certain cancers, while low levels can signal malnutrition, liver/kidney disease, or infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein and Fraction Breakdown Test

Frequently asked questions

What causes high total protein levels?
High total protein may be due to dehydration, multiple myeloma (a blood cancer), or certain chronic illnesses like heart failure. Your doctor will review your symptoms and other test results to determine the cause.
What does it mean if my albumin is low?
Low albumin often means your liver or kidneys aren’t producing or retaining enough protein. This can lead to swelling (edema), fatigue, or poor wound healing. Treatment may include dietary changes or medications to support protein synthesis.
Can diet affect these test results?
Yes, protein-rich foods can influence results. If your doctor ordered albumin specifically, avoid high-protein meals for 8–12 hours before testing. For total protein, a standard diet is fine, but fasting may be required for precise albumin measurement.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy