Tissue transglutaminase IgA antibody (serum/plasma)
This test measures the presence of antibodies against tissue transglutaminase, a protein linked to gluten sensitivity and celiac disease.
["Helps diagnose gluten-related disorders by detecting immune responses to gluten proteins."]
Key facts at a glance
- LOINC
- 14838-7
- Short code
- T gondii Tiss Ql Cult
- Synonyms
- T gondii Tiss Ql Cult
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- organism-specific-culture
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like persistent diarrhea, abdominal pain, weight loss, or fatigue, especially if you’ve been diagnosed with or suspected of having celiac disease, gluten sensitivity, or an autoimmune condition linked to gluten exposure. It may also be used in screening or monitoring for gluten-related disorders in certain populations.
What to Expect Before the Test
No special preparation is needed, but if you’re on a gluten-free diet, your provider may advise temporarily reintroducing gluten to assess your response. Avoid alcohol and certain medications (like blood thinners) that could affect test results if instructed by your doctor.
What the Test Involves
A small blood sample is drawn from a vein in your arm. The sample is sent to a lab where it’s analyzed for antibodies against tissue transglutaminase. The test is typically done on serum or plasma and takes about 24 hours to complete.
What the Results Mean
Positive results suggest an immune response to tissue transglutaminase, which may indicate celiac disease or gluten sensitivity. Negative results mean no detectable antibodies, but other tests or further evaluation may still be needed to confirm a diagnosis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
High levels of these antibodies are strongly associated with celiac disease, an autoimmune condition where gluten triggers damage to the small intestine. They can also appear in gluten sensitivity or other gluten-related disorders. Early detection is key to managing symptoms and preventing long-term complications like nutrient deficiencies or damage to other organs.
Short name
IgA Anti-TTG
Frequently asked questions
What does a positive result mean?
Can I eat gluten before the test?
How long does it take to get the results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy