Tetrahydrocortisone/Creatinine Ratio, Urine
This urine test measures a cortisol metabolite relative to creatinine, which helps account for variations in urine concentration.
["The result can help evaluate adrenal steroid production and metabolism when combined with your symptoms and other hormone tests."]
Key facts at a glance
- LOINC
- 81795-7
- Short code
- THcortisone/Creat Ur-sRto
- Synonyms
- THcortisone/Creat Ur-sRto
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures tetrahydrocortisone, a metabolite related to cortisol, in urine. It compares the amount of tetrahydrocortisone with the amount of creatinine, a substance normally released in urine, to reduce the effect of differences in urine concentration.
Why might I need this test?
A clinician may order this test to help evaluate adrenal hormone production or metabolism. It may be considered when symptoms suggest an adrenal or endocrine disorder, but the result is usually interpreted along with other hormone tests and medical findings.
How is the test performed?
A urine sample is analyzed in the laboratory for tetrahydrocortisone and creatinine. The laboratory then reports the amount of tetrahydrocortisone relative to the amount of creatinine.
How do I prepare for the test?
Follow the collection instructions provided by the laboratory, including whether a spot urine or a timed collection is required. Collect the sample at the specified time, keep it refrigerated if instructed, and return it promptly; do not change medication or supplement doses unless your clinician advises you to do so.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An abnormal result may indicate altered adrenal steroid production or metabolism, but this measurement is not specific to one condition by itself. Results should be interpreted with symptoms, medication use, other adrenal hormone tests, and the collection method because urine concentration and collection timing can affect interpretation.
Short name
Urine tetrahydrocortisone/creatinine ratio
Frequently asked questions
Is this the same as a urine cortisol test?
Why is creatinine included in the result?
Do I need to collect all of my urine for 24 hours?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy