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Theophylline (Serum/Plasma Mass Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of theophylline, a medication used to treat breathing problems like asthma or chronic obstructive pulmonary disease (COPD). It helps doctors monitor your dose to ensure it’s effective without causing too much side effects.

Quick summary

["This test helps adjust your medication to keep it at safe, effective levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
80967-3
Short code
Theophylline free SerPl-mCnc
Synonyms
Theophylline free SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
20
Critical range
— – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you’re taking theophylline (a bronchodilator) to manage breathing issues. Regular monitoring helps prevent side effects like rapid heart rate, nausea, or insomnia by ensuring your dose stays within a safe range.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample (either serum or plasma) via a simple venipuncture. If you’re on a diet or have taken certain medications recently, let your doctor know—it may affect results.

What the Results Mean

Results show your current theophylline level. While exact ranges vary by lab and patient, levels are typically checked to avoid toxicity or insufficient effectiveness. Your doctor will interpret these results in the context of your symptoms and medication.

Possible Side Effects of Theophylline

High levels can cause side effects like headaches, dizziness, or irregular heartbeat. Low levels may mean your medication isn’t working well. Always follow your doctor’s guidance on timing and dosage.

Reference range

Therapeutic: 10-20 mcg/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Monitoring for Safety and Effectiveness

Short name

Theophylline Level

Frequently asked questions

Why is this test important for my health?
This test ensures your theophylline dose is neither too high (risking toxicity) nor too low (risking poor asthma/COPD control). Regular monitoring helps prevent complications and optimize your treatment.
What if my test results are out of range?
If results are too high, your doctor may adjust your dose downward. If too low, they may increase it. Always discuss changes with your provider—never alter your medication without supervision.
Can diet or other medications affect this test?
Yes, some foods (like grapefruit) or other medications (e.g., cimetidine) can change how theophylline works in your body. Tell your doctor about all medications, supplements, or recent dietary changes.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy