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Theophylline Peak Concentration (Serum/Plasma)

Published: August 9, 2026Updated: August 17, 2026

This test measures the highest blood level of theophylline, a medication used to treat certain breathing and heart conditions. It helps doctors monitor how well your body is handling the drug over time.

Quick summary

["This test ensures your theophylline levels stay safe and effective for managing your condition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
32115-8
Short code
Theophylline Peak SerPl-sCnc
Synonyms
Theophylline Peak SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
20
Critical range
— – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Theophylline is a medication often prescribed for conditions like asthma, chronic obstructive pulmonary disease (COPD), or heart rhythm disorders. Keeping levels too high can cause side effects, while levels that are too low may mean the medication isn’t working properly. This test helps prevent these issues by checking your peak concentration right after you take the dose.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm or vein to draw blood. The process usually takes a few minutes. If you’re on a theophylline infusion (like through an IV), your provider may check your blood level at a specific time during treatment.

What the Results Mean

Results from this test help your healthcare provider adjust your medication dose if needed. They’ll compare your peak level to your lowest level (trough) and any other test results to find the right balance for your condition. Always follow your provider’s guidance on interpreting these results.

Common Reasons for Testing

Your doctor might order this test if you’re on long-term theophylline therapy, if you’re experiencing side effects like nausea, headaches, or rapid heartbeat, or if you’re having trouble controlling your symptoms. It’s also used to check if the medication is working as intended.

Reference range

Therapeutic: 10-20 mcg/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Theophylline is a narrow therapeutic window medication, meaning small changes in blood levels can lead to serious side effects or reduced effectiveness. Peak levels help identify whether your dose is too high or too low. Regular monitoring is especially important if you have liver or kidney issues, take other medications that interact with theophylline, or have certain health conditions like heart disease.

Short name

Theophylline Peak Level

Frequently asked questions

How often should I expect this test?
The frequency depends on your treatment plan. Some patients need this test monthly or quarterly, while others may only need it if their symptoms or lab results change. Your healthcare provider will let you know how often to get it.
What happens if my theophylline levels are too high?
If your peak level is too high, your doctor may adjust your dose, prescribe a different medication, or monitor you more closely for side effects like rapid heart rate, tremors, or trouble sleeping. They’ll work with you to find the safest and most effective level for your condition.
Can I eat or drink before this test?
You can eat and drink normally before this test, as it doesn’t require fasting. However, always follow your healthcare provider’s instructions, as some medications or foods might affect your blood test results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy