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Theophylline Level (Mass Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of theophylline, a medication derived from tea leaves, in your blood. It helps monitor your levels to ensure they stay within safe therapeutic ranges.

Quick summary

["This test checks if your theophylline medication is working properly and at safe levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
4048-5
Short code
Theophylline Sal-mCnc
Synonyms
Theophylline Sal-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
20
Critical range
— – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order a theophylline test if you’re taking medications containing theophylline (such as aminophylline or theophylline itself) to manage conditions like asthma, chronic obstructive pulmonary disease (COPD), or other breathing-related issues. It helps prevent dangerous levels of the medication that could cause side effects or health risks.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into a vein in your arm, or a blood sample may be collected from a finger prick. If you’re on a regular medication schedule, let your healthcare provider know to ensure timing aligns with your usual dose.

What the Test Results Mean

Theophylline levels are measured in micrograms per milliliter (mcg/mL). Results help determine if your dose is too high or too low. High levels may cause nausea, rapid heart rate, or other symptoms, while low levels might mean your medication isn’t working effectively.

Possible Side Effects or Risks

While rare, very high theophylline levels can lead to serious side effects like seizures, irregular heartbeat, or even heart failure. Your doctor will adjust your medication based on these results to keep you safe.

Reference range

Therapeutic: 10-20 mcg/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Theophylline

Frequently asked questions

What causes theophylline levels to be checked?
Your doctor may check your theophylline levels if you’re taking this medication to manage breathing issues, if you experience side effects like rapid heartbeat or nausea, or if you’re adjusting your dose.
What happens if my theophylline levels are too high?
High levels can cause symptoms like headache, dizziness, or irregular heartbeat. Your doctor will likely reduce your dose or switch to a different medication to bring your levels back into a safe range.
Can I eat or drink before this test?
You can eat and drink normally before this test unless your doctor specifies otherwise. No special fasting is required.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy