Skip to content

Threonine/Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

Measures urinary threonine relative to creatinine to help assess amino acid excretion and metabolism.

Quick summary

["This urine test can help identify abnormal threonine excretion and guide evaluation of nutrition, kidney function, or inherited metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22688-6
Short code
Threonine/Creat Ur-sRto
Synonyms
Threonine/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of threonine, an essential amino acid, in urine relative to the amount of creatinine. Creatinine is used as a reference marker that helps account for differences in urine concentration.

Why might I need this test?

A urine threonine-to-creatinine ratio may be used to evaluate amino acid metabolism, investigate excessive urinary loss of threonine, or monitor nutrition and treatment in people with kidney or inherited metabolic conditions.

How is the test performed?

A urine sample is collected and analyzed to measure threonine and creatinine. The results are compared to calculate the threonine-to-creatinine ratio.

How do I prepare for the test?

Follow your healthcare professional's instructions about when and how to collect the urine sample. Fasting is not usually required unless you are specifically told to avoid certain foods or supplements.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine threonine-to-creatinine ratio

Frequently asked questions

Why is creatinine included in this urine test?
Creatinine helps show how concentrated the urine is. Comparing threonine with creatinine makes the result less dependent on variations in urine concentration.
Do I need to fast before this test?
Fasting is generally not needed, but your clinician may give specific instructions if the test is being used to monitor nutrition or a metabolic disorder.
Does an abnormal result mean I have an inherited metabolic disorder?
Not by itself. An abnormal result can have several causes and is usually interpreted alongside medical history, medications, diet, and additional laboratory tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy