Skip to content

Serum/plasma concentration of total bilirubin

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of bilirubin in your blood, a waste product made when red blood cells break down. It helps assess liver function and detect conditions like jaundice or bile duct blockages.

Quick summary

["Your liver’s ability to process bilirubin and detect potential liver or bile issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
93689-8
Short code
THSD7A IgG Titr SerPl CBA IFA
Synonyms
THSD7A IgG Titr SerPl CBA IFA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cba-ifa
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Bilirubin is produced when your body breaks down old red blood cells. Normally, your liver removes it from your blood and sends it to your bile ducts to be excreted in bile. If your liver isn’t working properly, bilirubin can build up in your blood, leading to jaundice (yellowing of the skin and eyes). This test helps doctors check for liver diseases, infections, or blockages in the bile ducts.

What to Expect Before the Test

No special preparation is usually needed. You may have a small needle inserted into a vein (usually in your arm) to draw blood. If you’re tested for urine bilirubin (not applicable here), you might be asked to collect a urine sample in a container. Avoid alcohol or certain medications for 24 hours before testing if instructed by your doctor.

What the Results Mean

Higher than normal levels of bilirubin can indicate liver problems, such as hepatitis, cirrhosis, or bile duct issues. Lower levels may suggest hemolytic anemia (where red blood cells break down too quickly). Your doctor will interpret your results in the context of your overall health and symptoms.

Common Conditions This Test Helps Diagnose

This test is often used to diagnose or monitor conditions like jaundice, liver diseases (such as hepatitis), bile duct blockages, or hemolytic anemia. It can also help track how well treatments are working for these conditions.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated bilirubin levels often signal liver dysfunction or impaired bile flow, which can cause jaundice, fatigue, or abdominal pain. Doctors may use these results alongside other tests to diagnose liver diseases, gallbladder issues, or blood disorders that affect red blood cell breakdown.

Short name

Total bilirubin

Frequently asked questions

What causes bilirubin levels to rise?
Bilirubin levels can rise due to liver problems (like hepatitis or cirrhosis), blockages in the bile ducts, or conditions where red blood cells break down faster than the liver can process them (such as hemolytic anemia). Lifestyle factors like heavy alcohol use or certain medications may also play a role.
How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab. Your doctor will discuss the findings with you during your follow-up visit.
Can diet affect bilirubin levels?
Diet alone usually doesn’t significantly affect bilirubin levels, but certain foods (like excessive fiber or specific supplements) may interact with liver function indirectly. Always follow your doctor’s advice regarding diet and medications.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy