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Thyroglobulin (Serum) - Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of thyroglobulin, a protein produced by thyroid cells, in your blood. It helps assess thyroid function, especially after thyroid surgery or treatment for thyroid cancer.

Quick summary

["Thyroglobulin levels can indicate thyroid health and response to treatment for thyroid-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53920-5
Short code
Thyroglob LN FNA-mCnc
Synonyms
Thyroglob LN FNA-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to monitor thyroid function, check for thyroid cancer recurrence, or evaluate thyroid hormone production. It’s often used after thyroid surgery or radioactive iodine treatment to ensure the thyroid gland is fully removed or damaged.

What Does a Result Mean?

Results can vary based on your health, treatment, and other factors. High levels may suggest thyroid cancer or overactivity, while low levels could indicate thyroid removal or damage. Your doctor will interpret results in the context of your medical history.

Common Uses in Healthcare

This test is frequently used in follow-up care for patients with thyroid nodules, thyroid cancer, or Hashimoto’s disease. It helps track changes over time and guide treatment decisions.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab for analysis. You may be asked to fast for 8–12 hours before the test if instructed by your doctor.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Thyroglobulin

Frequently asked questions

What causes abnormal thyroglobulin levels?
Abnormal results may be due to thyroid cancer, thyroid nodules, or conditions affecting thyroid function. Your doctor will consider other tests and symptoms to diagnose the cause.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your doctor will contact you once results are ready.
Can I eat or drink before this test?
Follow your doctor’s instructions. Some tests require fasting, while others do not. Avoid caffeine or alcohol before the test if specified.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy