Thyroid Stimulating Hormone (TSH) with Antibody Screening (Thyroglobulin Antibody Profile)
This test measures your thyroid-stimulating hormone (TSH) level and checks for antibodies against thyroglobulin, a protein produced by thyroid cells. It helps evaluate thyroid function and detect autoimmune thyroid conditions.
["Assesses thyroid health and autoimmune thyroid disease risk with two key tests in one panel."]
Key facts at a glance
- LOINC
- 101568-4
- Short code
- Thyroglob + Thyroglob Ab pnl Tiss FNA
- Synonyms
- Thyroglob + Thyroglob Ab pnl Tiss FNA
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 136
- Ref high
- 145
- Critical range
- 120 N/A – 160 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 84295
- SNOMED
- 110741000
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters for Your Health
Your thyroid gland produces hormones that regulate metabolism, energy, and other vital functions. TSH is a hormone from your pituitary gland that tells your thyroid how much hormone to make. High or low TSH levels can signal thyroid problems, such as hypothyroidism or hyperthyroidism. This test also looks for antibodies that may indicate an autoimmune response targeting your thyroid cells, which can cause conditions like Hashimoto’s thyroiditis or Graves’ disease.
How the TSH Test Works
Your blood sample is tested for TSH levels using a sensitive immunoassay method. This measures how much TSH is in your bloodstream. The test also detects thyroglobulin antibodies, which are proteins your immune system mistakenly targets in autoimmune thyroid diseases.
What Your Results Might Mean
If your TSH is too high, it may mean your thyroid isn’t working well enough (hypothyroidism). If it’s too low, your thyroid might be overactive (hyperthyroidism). Antibody results could indicate an autoimmune thyroid condition, which may require further evaluation or treatment.
Common Causes and Conditions
This test is often ordered if you have symptoms like fatigue, weight changes, hair loss, or unexplained goiter. It may also be used after thyroid surgery or radiation treatment to monitor recovery. Autoimmune thyroid diseases, such as Hashimoto’s or Graves’ disease, can also trigger this test.
Reference range
Adult: 136-145 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Detecting Thyroid Disorders Early
Short name
TSH + Thyroglobulin Antibody Check
Frequently asked questions
What does a high or low TSH level mean for my health?
Will this test show if I have thyroid cancer?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy