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Thyroglobulin (serum/plasma) concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of thyroglobulin, a protein produced by thyroid cells, in your blood. It helps assess thyroid function, especially after thyroid surgery or treatment for thyroid cancer.

Quick summary

["Thyroglobulin levels can indicate thyroid health and response to treatment."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53922-1
Short code
Thyroglob Tiss FNA-mCnc
Synonyms
Thyroglob Tiss FNA-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you’ve had thyroid surgery, radioactive iodine treatment, or if you have a history of thyroid cancer. It can also help monitor thyroid function in people with thyroid nodules or autoimmune thyroid disease.

What to Expect Before the Test

No special preparation is usually needed, but your doctor may advise avoiding certain medications or dietary supplements that could affect results. Blood is drawn from a vein, typically in your arm.

What the Results Mean

Thyroglobulin levels can vary widely. Low levels may suggest thyroid underactivity or treatment success, while elevated levels could indicate thyroid cancer recurrence or other thyroid issues. Your doctor will interpret results in the context of your medical history.

Common Reasons for Abnormal Results

Elevated levels might signal thyroid cancer or thyroiditis (inflammation). Low levels could be due to thyroid hormone replacement therapy or other conditions. Always discuss results with your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Thyroglobulin

Frequently asked questions

What happens if my test results are abnormal?
If your thyroglobulin levels are abnormal, your doctor may recommend further testing, such as ultrasound imaging or additional blood tests, to investigate the cause. They may also adjust treatment plans if needed.
Can diet or medications affect this test?
Certain medications (like thyroid hormone replacements) or dietary supplements (e.g., selenium) can influence thyroglobulin levels. Your doctor may suggest temporarily stopping these before testing if advised.
Is this test painful or uncomfortable?
The blood draw is generally mild discomfort for a few minutes, but most people tolerate it well. You may feel slight bruising or soreness at the site, which usually fades quickly.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy