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Thyroglobulin Antibody (Thyroid Colloid Antibody), Serum — Qualitative

Published: August 9, 2026Updated: August 16, 2026

A blood test that looks for antibodies against thyroid colloid, a protein stored in the thyroid gland.

Quick summary

["This test helps evaluate the possibility of an autoimmune thyroid condition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63407-1
Short code
Thyroid Colloidal Ab Ser Ql IF
Synonyms
Thyroid Colloidal Ab Ser Ql IF
Category
thyroid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test checks for thyroid colloid antibodies, also called thyroglobulin antibodies. These antibodies are directed against thyroglobulin, a protein stored in the thyroid gland.

Why might I need this test?

Your clinician may order this test when symptoms or other thyroid tests suggest an autoimmune thyroid disorder. It is often included with thyroid antibody testing, such as thyroid peroxidase antibody testing.

How is the test performed?

A blood sample is collected and analyzed in a laboratory for the presence of thyroid colloid antibodies. This is generally a qualitative test, reported as positive or negative, although some laboratories may also provide a measured level.

How do I prepare for the test?

Fasting is usually not required. Tell your clinician about any biotin-containing supplements because some laboratory methods can be affected by them, and do not stop prescribed medicines unless instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result may occur with autoimmune thyroid conditions, including Hashimoto thyroiditis and Graves disease. Antibodies can also be present in some people without thyroid disease, so the result must be interpreted with symptoms, thyroid function tests, and other antibody findings. A negative result does not completely rule out an autoimmune thyroid condition.

Short name

Thyroid colloid antibody

Frequently asked questions

What does a positive thyroid colloid antibody result mean?
It means antibodies against thyroid colloid, or thyroglobulin, were detected. This can support an autoimmune thyroid diagnosis but may also be found in people without thyroid disease.
Is this the same as a thyroid peroxidase antibody test?
No. This test looks for antibodies to thyroid colloid, while a thyroid peroxidase antibody test looks for a different antibody associated with the thyroid.
Do I need to fast or stop thyroid medication before this test?
Fasting is generally unnecessary. Continue taking prescribed medicines unless your clinician gives different instructions, and mention any supplements that contain biotin.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy