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IgG Antibody to Borrelia burgdorferi (Lyme Disease) by Immunoassay

Published: August 9, 2026Updated: August 17, 2026

This test measures antibodies in your blood that your immune system produces in response to *Borrelia burgdorferi*, the bacterium responsible for Lyme disease. It helps doctors determine if you’ve been exposed to Lyme bacteria.

Quick summary

["This test helps diagnose Lyme disease by detecting past or current infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
101409-1
Short code
Tick IgG Ab Pnl Ser
Synonyms
Tick IgG Ab Pnl Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
22
Ref high
198
Critical range
— – 10000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82553
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test looks for IgG antibodies specific to *Borrelia burgdorferi*, a type of bacteria transmitted by ticks. These antibodies develop after your body has encountered the bacteria, either through infection or vaccination. The presence of these antibodies suggests exposure, but they don’t always mean an active infection—more testing may be needed to confirm current illness.

Why Might You Need This Test?

Doctors may order this test if you’ve had symptoms like fever, rash (e.g., bull’s-eye rash), joint pain, or neurological issues that could be linked to Lyme disease, especially after a tick bite or in areas where Lyme is common. It’s also used to monitor past infections or guide treatment decisions.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it’s analyzed using an immunoassay method to detect the specific antibodies. Results are reported as positive, negative, or equivocal (needs further evaluation).

What Are Possible Results?

A **negative** result means no detectable antibodies were found, suggesting no current infection or very early exposure. A **positive** result indicates likely exposure, but further testing (like a Western blot) may be needed to confirm Lyme disease. An **equivocal** result may require additional testing to clarify.

Reference range

Adult males: 22-198 U/L; Females: 22-198 U/LN/A

Specimen: serum

No special preparation required. Inform provider of any chest pain or symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lyme Disease IgG Antibody

Frequently asked questions

Can I get Lyme disease if my test is negative?
A negative result doesn’t always mean you’re completely free of Lyme disease. Early infection may not yet produce detectable antibodies, or symptoms could be mild. If you suspect Lyme, follow up with your doctor, especially if you’ve had a tick bite or live in a high-risk area.
What if my test is positive but I don’t have symptoms?
Positive results often mean past exposure, not necessarily an active infection. Some people develop antibodies without symptoms. Your doctor will assess your medical history, symptoms, and other tests to guide treatment if needed.
How soon after infection can I get this test?
Antibodies typically appear within 2–6 weeks after infection, but some people may not develop them for months. If you suspect Lyme disease, ask your doctor about additional testing sooner if symptoms appear early.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy