IgG Antibody to Borrelia burgdorferi (Lyme Disease) by Immunoassay
This test measures antibodies in your blood that your immune system produces in response to *Borrelia burgdorferi*, the bacterium responsible for Lyme disease. It helps doctors determine if you’ve been exposed to Lyme bacteria.
["This test helps diagnose Lyme disease by detecting past or current infection."]
Key facts at a glance
- LOINC
- 101409-1
- Short code
- Tick IgG Ab Pnl Ser
- Synonyms
- Tick IgG Ab Pnl Ser
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 22
- Ref high
- 198
- Critical range
- — – 10000 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82553
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test looks for IgG antibodies specific to *Borrelia burgdorferi*, a type of bacteria transmitted by ticks. These antibodies develop after your body has encountered the bacteria, either through infection or vaccination. The presence of these antibodies suggests exposure, but they don’t always mean an active infection—more testing may be needed to confirm current illness.
Why Might You Need This Test?
Doctors may order this test if you’ve had symptoms like fever, rash (e.g., bull’s-eye rash), joint pain, or neurological issues that could be linked to Lyme disease, especially after a tick bite or in areas where Lyme is common. It’s also used to monitor past infections or guide treatment decisions.
How Is the Test Performed?
A blood sample is taken from a vein in your arm. The sample is sent to a lab where it’s analyzed using an immunoassay method to detect the specific antibodies. Results are reported as positive, negative, or equivocal (needs further evaluation).
What Are Possible Results?
A **negative** result means no detectable antibodies were found, suggesting no current infection or very early exposure. A **positive** result indicates likely exposure, but further testing (like a Western blot) may be needed to confirm Lyme disease. An **equivocal** result may require additional testing to clarify.
Reference range
Adult males: 22-198 U/L; Females: 22-198 U/LN/A
No special preparation required. Inform provider of any chest pain or symptoms.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Lyme Disease IgG Antibody
Frequently asked questions
Can I get Lyme disease if my test is negative?
What if my test is positive but I don’t have symptoms?
How soon after infection can I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy