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Total Immunoglobulin E (IgE) Level

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin E (IgE) in your blood. IgE is a type of antibody that your immune system produces in response to allergens.

Quick summary

["IgE levels help identify allergies or immune system responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61296-0
Short code
Timothy IgE/IgE total %
Synonyms
Timothy IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does IgE Measure?

IgE (Immunoglobulin E) is a protein produced by your immune system when exposed to allergens like pollen, dust, or certain foods. High levels of IgE can signal an allergic reaction or an overactive immune response.

Why Might You Need This Test?

Doctors may order this test to diagnose allergies, evaluate conditions like asthma, chronic urticaria (hives), or certain immune disorders. It can also help monitor treatment progress or rule out allergies in unclear cases.

Sample Collection and Preparation

A blood sample is taken from a vein in your arm. The sample is sent to a lab for analysis. No special preparation is needed, but fasting may not be required unless instructed by your healthcare provider.

What to Expect During the Test

The process is quick and usually painless. You may feel a slight pinch or discomfort when the needle is inserted, but most people tolerate it well. You can resume normal activities immediately afterward.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated IgE levels often indicate allergies, hypersensitivity reactions, or immune system conditions like atopic dermatitis. Very high levels may suggest parasitic infections or severe allergic disorders. Low levels might be seen in certain immune deficiencies or during recovery from allergies. Always discuss results with your healthcare provider for personalized interpretation.

Short name

IgE Total

Frequently asked questions

When Might I See Elevated IgE Levels?
Elevated IgE levels can occur with allergies (e.g., to pollen, pet dander, or foods), asthma, eczema, or chronic hives. They may also be linked to certain infections or immune disorders.
When Might My IgE Levels Be Low?
Low IgE levels can occur in people with certain immune deficiencies, after successful allergy treatment, or in conditions like common variable immunodeficiency. They may also be normal in some individuals without allergies.
Does IgE Test Help with Allergy Treatment?
Yes, IgE levels can guide allergy treatments. High levels may prompt allergy testing (skin or blood) to identify specific triggers. Doctors may use IgE results to tailor immunotherapy (allergy shots) or other treatments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy