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Total Antioxidant Capacity of Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s ability to neutralize harmful free radicals, which can help protect cells from damage.

Quick summary

["Assesses your body’s natural antioxidant defenses in serum samples."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61321-6
Short code
TMA IgE/IgE total %
Synonyms
TMA IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Total antioxidant capacity (TAC) reflects the combined activity of various antioxidants in your blood, such as vitamins (e.g., vitamin C, E), glutathione, and enzymes. These compounds work together to prevent oxidative stress, which can damage cells and contribute to chronic diseases.

Why Might You Need This Test?

Doctors may order this test to evaluate overall oxidative health, especially in conditions linked to oxidative damage (e.g., cardiovascular disease, diabetes, or aging). It can also help monitor treatment responses in certain chronic illnesses.

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The serum portion is then analyzed to measure its antioxidant capacity using a specialized lab method that detects the total neutralizing ability of antioxidants present.

What Are Common Uses?

This test isn’t routinely part of standard health screenings but may be used in specialized settings, such as research studies, athletic performance assessments, or evaluating antioxidant supplementation effects.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Antioxidant Level

Frequently asked questions

What does a high or low result mean?
A high result suggests robust antioxidant protection, which may be beneficial for overall health. A low result may warrant discussion with your doctor about dietary antioxidants, lifestyle factors, or underlying conditions affecting antioxidant levels.
How often should I get this test?
This test isn’t typically recommended for routine check-ups. Ask your doctor if it’s appropriate for your specific health needs or if it’s part of a specialized evaluation.
Can diet or supplements affect this test?
Yes, dietary antioxidants (e.g., fruits, vegetables, omega-3s) and supplements (e.g., vitamins C/E) can influence results. Avoid high-antioxidant foods or supplements for 24 hours before testing if instructed by your lab.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy