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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help doctors assess overall health and detect conditions like malnutrition or kidney disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
54099-7
Short code
TMPA Ur-mCnc
Synonyms
TMPA Ur-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for signs of kidney disease, liver problems, infections, or nutritional deficiencies. It can also help diagnose conditions like multiple myeloma or certain autoimmune disorders.

What Does the Result Mean?

Higher-than-normal levels might suggest conditions like dehydration, multiple myeloma, or liver disease. Lower-than-normal levels could indicate malnutrition, kidney disease, or severe infections.

Common Conditions Monitored

This test is often used to monitor kidney function, liver health, and overall protein balance in the body, especially in patients with chronic illnesses.

Sample Collection and Preparation

A blood sample is typically drawn from a vein in your arm. The blood is then separated into serum (after clotting) or plasma (after anticoagulant use) for testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes high total protein levels?
High total protein levels may be due to conditions like dehydration, multiple myeloma, or certain liver diseases. Chronic infections or inflammatory conditions can also contribute.
What causes low total protein levels?
Low total protein levels often result from malnutrition, kidney disease, severe infections, or conditions affecting protein synthesis in the liver.
How often should I get this test?
The frequency depends on your health condition. Doctors may recommend this test periodically if you have chronic illnesses like kidney disease, liver disease, or cancer. Follow your healthcare provider’s advice.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy