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Total Protein with Serum/Plasma Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immune function, and transport nutrients.

Quick summary

["Your blood protein levels can signal health issues or help guide treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
515-7
Short code
TMP SMX Islt MLC
Synonyms
TMP SMX Islt MLC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mlc
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test to check for conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help monitor protein-losing disorders or evaluate responses to treatments that affect protein levels.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm or vein to draw blood. If you’re nervous, let your healthcare provider know—they can help make it more comfortable.

What the Results Mean

Higher-than-normal protein levels might indicate conditions like multiple myeloma or severe dehydration. Lower-than-normal levels could suggest malnutrition, liver or kidney disease, or certain inflammatory conditions. Your doctor will interpret results in the context of your overall health.

Common Conditions Affecting Protein Levels

Protein levels can drop due to chronic liver disease, kidney failure, or conditions like celiac disease that interfere with nutrient absorption. They may rise in cases of severe dehydration, infections, or certain cancers.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein levels can signal underlying health issues that need attention. For example, low protein might mean your body isn’t getting enough nutrients, while high protein could point to conditions like kidney disease or immune system disorders. Regular monitoring helps track how well treatments are working.

Short name

Total Protein

Frequently asked questions

How often should I get this test?
Your doctor will decide how often you need this test based on your health status, symptoms, or treatment plan. Some people get it once a year, while others may need it more often if they have ongoing conditions like kidney disease or liver problems.
What does a ‘normal’ range mean for me?
There’s no single ‘normal’ range for everyone—it depends on factors like age, sex, and overall health. Your doctor will compare your results to your own baseline or to ranges appropriate for your situation. They’ll explain what your specific results mean for you.
Can diet affect my protein test results?
Yes, diet can influence protein levels. Eating enough protein-rich foods (like lean meats, dairy, beans, or whole grains) supports normal levels. Conversely, poor nutrition, extreme weight loss, or certain medical diets (like low-protein diets) may lower protein levels. Always follow your doctor’s advice on diet and testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy