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Total Alpha and Gamma-Tocopherol and -Tocotrienol Levels (Serum)

Published: August 9, 2026Updated: August 17, 2026

This test measures the combined levels of vitamin E compounds—specifically alpha-tocopherol and tocotrienols—in your blood serum. Vitamin E is important for protecting cells from oxidative damage.

Quick summary

["This test helps assess your vitamin E status and potential oxidative stress risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
87672-2
Short code
Tocopherol+tocotrienol Spec-mCnt
Synonyms
Tocopherol+tocotrienol Spec-mCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
5
Ref high
20
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to vitamin E deficiency, such as nerve damage, muscle weakness, or certain genetic disorders. It may also be used to monitor vitamin E levels in people taking supplements or with conditions affecting fat absorption (e.g., cystic fibrosis).

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Avoid taking vitamin E supplements for 24 hours before the test if possible.

What the Test Involves

A healthcare professional will draw blood from a vein in your arm. The blood sample will be sent to a lab for analysis using a high-performance liquid chromatography (HPLC) method to separate and measure the different vitamin E compounds.

What the Results Mean

Results provide a profile of your total vitamin E status, including alpha-tocopherol (the most biologically active form) and tocotrienols (another form of vitamin E with antioxidant properties). Low levels may indicate deficiency or malabsorption, while high levels could suggest excessive intake or certain genetic conditions.

Reference range

NCBI: Vitamin E 5-20 µg/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Tocopherols/Tocotrienols (Serum)

Frequently asked questions

Clinical Significance
Low levels of vitamin E (tocopherols/tocotrienols) may be associated with oxidative stress, nerve damage (neuropathy), muscle weakness, or certain metabolic disorders. High levels may be seen in people with genetic disorders like *alpha-tocopherol transfer protein deficiency* or those taking high-dose vitamin E supplements. Monitoring these levels helps guide treatment for deficiencies or manage conditions like chronic oxidative stress.
What Does a Low Level Mean?
A low level of vitamin E in your blood may suggest a deficiency, which can affect nerve function, immune health, or fat-soluble vitamin absorption. Your provider may recommend dietary changes, supplements, or further testing if needed.
What Does a High Level Mean?
High levels of vitamin E can occur due to genetic conditions, excessive supplementation, or certain medications. While rare, very high levels may raise concerns about potential toxicity, especially if taken long-term. Your provider will interpret results in the context of your overall health and medical history.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy