TP53 Gene Deletion in Blood (Genetic Test)
This test checks for deletions in the TP53 gene, which is commonly involved in cancer development. It may be ordered if you have symptoms or a family history suggesting a higher risk for certain cancers.
["A TP53 gene deletion could indicate an increased cancer risk, but results require medical review by a healthcare provider."]
Key facts at a glance
- LOINC
- 96970-9
- Short code
- TP53 gene Del+Dup Bld/T
- Synonyms
- TP53 gene Del+Dup Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The TP53 gene is a tumor suppressor, meaning it normally helps prevent uncontrolled cell growth. A deletion in this gene may reduce its ability to function properly. This test looks for specific changes (deletions) in the TP53 gene sequence in your blood sample, which could be linked to inherited or acquired cancer risks.
Why It Might Be Ordered
Your doctor may recommend this test if you have a personal or family history of certain cancers (e.g., breast, ovarian, colon, or lung cancer), unexplained symptoms like fatigue or unexplained weight loss, or if you’re part of a genetic testing program for cancer predisposition.
Sample Collection and Process
A small amount of blood is drawn from your arm. The sample is then analyzed in a lab to detect genetic changes in the TP53 gene. Results are compared to a reference database of known genetic variations.
What the Results Mean
Results may show a deletion in the TP53 gene, which could be associated with an increased risk of certain cancers. However, this alone does not diagnose cancer. Your healthcare provider will discuss the results in the context of your medical history and symptoms.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
TP53 Mutation Screening (blood)
Frequently asked questions
What does a positive result mean?
How often should I get this test?
Can lifestyle changes affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy