TP53 Gene Mutation Analysis (Blood)
This test checks for specific changes (mutations) in the TP53 gene, which is commonly linked to cancer development. Mutations in TP53 are found in many types of cancer, including those of the breast, lung, colon, and blood.
["This test helps doctors assess cancer risk, guide treatment decisions, or monitor cancer progression."]
Key facts at a glance
- LOINC
- 21739-8
- Short code
- TP53 gene Mut Anl Bld/T
- Synonyms
- TP53 gene Mut Anl Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you have a family history of cancer, especially if multiple relatives have been diagnosed with the same type. It could also be part of a cancer screening or diagnostic evaluation if you’ve been diagnosed with cancer or have symptoms that suggest a genetic predisposition.
What the Test Involves
A small blood sample is taken from you, usually from your arm. The blood is then analyzed in a lab to detect any mutations in the TP53 gene. This process helps identify whether the gene has been altered in a way that could contribute to cancer.
What to Expect Before the Test
No special preparation is needed for this test. You may be asked to fast or avoid certain medications, but your doctor will provide specific instructions if applicable. Bring any relevant medical records or family history details to your appointment.
What to Expect After the Test
After the blood sample is taken, you can resume your normal activities immediately. You may experience mild discomfort or bruising at the injection site, but this usually fades quickly. Follow-up instructions from your doctor will depend on your test results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Mutations in the TP53 gene are among the most common genetic changes found in cancer. Detecting these mutations can help doctors determine the best treatment options, such as targeted therapies or chemotherapy. It may also influence decisions about cancer surveillance or genetic counseling for family members.
Short name
TP53 Mutation Test
Frequently asked questions
How Does This Test Differ from Other Genetic Tests?
What Are the Possible Results and What Do They Mean?
Can This Test Be Done Alongside Other Cancer-Related Tests?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy