Protein Electrophoresis (Serum) with Bromocresol Green (BCG) Dye Shift Analysis
This test measures the distribution of proteins in your blood using a dye called bromocresol green to help identify abnormal protein patterns, which may indicate conditions like multiple myeloma, liver disease, or other disorders.
["This test helps doctors check for unusual protein levels that might signal health concerns."]
Key facts at a glance
- LOINC
- 5989-9
- Short code
- tPA 10M PPP Chro-aCnc
- Synonyms
- tPA 10M PPP Chro-aCnc
- Category
- chemistry
- Sample
- plasma
- Container
- Lavender-top (EDTA) or Green-top (Heparin)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- chromo
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
Protein electrophoresis separates blood proteins into different fractions (e.g., albumin, globulins) based on size and charge. Bromocresol green dye binds to proteins, shifting its color depending on protein concentration. This helps detect shifts in protein patterns that may not be visible with standard tests.
Why Might You Need This Test?
Your doctor may order this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if they suspect conditions like multiple myeloma, kidney disease, or liver problems. It’s also used to monitor treatment progress for certain disorders.
How Is the Sample Collected?
A small blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum (the liquid part after clotting) for testing.
What Are Common Results?
Results show the relative amounts of different protein fractions. Abnormal patterns (e.g., high spikes in certain globulins) may indicate underlying health issues. Your doctor will interpret results in the context of your symptoms and medical history.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is critical for diagnosing and managing conditions affecting protein balance in the blood. For example, multiple myeloma often shows a distinct protein spike (M-protein) on electrophoresis. It can also help assess liver or kidney function by detecting abnormal protein synthesis or breakdown.
Short name
BCG Protein Electrophoresis
Frequently asked questions
What does a 'shift' in bromocresol green dye mean?
How long does it take to get results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy