Skip to content

Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels in blood and compares the amounts of albumin and globulin proteins, which can help assess protein balance and potential issues like malnutrition or inflammation.

Quick summary

["Understanding your protein balance helps doctors diagnose and monitor conditions affecting protein levels or function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22585-4
Short code
T palldm Ab Bld-aCnc
Synonyms
T palldm Ab Bld-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein includes two main types of proteins: albumin and globulin. Albumin helps maintain fluid balance in your body, while globulins support immune function and transport certain substances. Together, they provide insight into overall protein health.

How Is Albumin-to-Globulin Ratio Used?

The ratio compares albumin and globulin levels. A higher albumin-to-globulin ratio may suggest conditions like malnutrition, while a lower ratio could indicate inflammation, liver disease, or other immune-related issues.

Why Might This Test Be Ordered?

Your doctor may order this test to evaluate protein deficiencies, check for chronic diseases like kidney or liver problems, or monitor conditions affecting protein synthesis or breakdown.

What Can Abnormal Results Indicate?

Low total protein or an abnormal ratio might signal malnutrition, infections, autoimmune disorders, or organ dysfunction. High levels could suggest dehydration or conditions like multiple myeloma.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test helps identify imbalances that may require further medical evaluation, such as blood tests for liver function, kidney function, or nutritional assessment.

Short name

Protein Profile

Frequently asked questions

Why do I need this test?
Your doctor may recommend it to check if you have conditions affecting protein levels, such as chronic illness, kidney or liver problems, or poor nutrition.
How is the test performed?
A blood sample is taken from a vein in your arm. The sample is sent to a lab where proteins are analyzed to measure total protein and the ratio of albumin to globulin.
What are the typical results?
Results are reported as a ratio (albumin:globulin) and total protein levels. Exact ranges vary by lab, and your doctor will interpret results in the context of your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy