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Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and compares albumin to globulin proteins, which can help assess protein balance and potential issues like malnutrition or inflammation.

Quick summary

["Check protein health and inflammation risk with this simple blood test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13288-6
Short code
T palldm Ab Bld IF-aCnc
Synonyms
T palldm Ab Bld IF-aCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein includes albumin and globulin proteins produced by your liver and immune system. Albumin helps maintain fluid balance, while globulins support immune function and blood clotting. Together, they reflect overall protein status in your bloodstream.

How Is the Albumin-to-Globulin Ratio Used?

The ratio compares albumin (the smaller fraction) to globulin (the larger fraction). A lower albumin-to-globulin ratio may suggest conditions like malnutrition, liver disease, or chronic inflammation, while higher ratios could indicate immune system overactivity.

Why Might This Test Be Ordered?

Your doctor may order this test if you have symptoms like swelling, unexplained weight loss, fatigue, or signs of infection. It’s also used to monitor conditions like kidney disease, liver disorders, or autoimmune diseases.

What Does a Low or High Ratio Mean?

A low ratio may indicate protein loss (e.g., kidney disease), poor nutrition, or liver problems. A high ratio could signal overactive immune responses or conditions like multiple myeloma. Results alone don’t diagnose a specific condition—your doctor will consider your symptoms and other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein Balance and Disease Indication

Short name

Total Protein & AG Ratio

Frequently asked questions

Why do I need this test if I feel healthy?
Even without symptoms, this test helps detect subtle imbalances in protein levels that could signal underlying issues like chronic inflammation, liver or kidney strain, or nutritional deficiencies. Early detection can guide treatment decisions.
Will I need to prepare for this test?
No special preparation is needed. You may fast for 8–12 hours before the draw if your lab requires it, but confirm with your healthcare provider. Wear a comfortable shirt for easy access.
How long will results take?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Follow up with your doctor to discuss findings and next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy