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Total Protein with Albumin and Globulin Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels in your blood and breaks them down into albumin and globulin fractions, which help assess protein balance and potential health issues.

Quick summary

["Understanding your protein balance can help identify conditions like malnutrition, liver disease, or immune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98216-5
Short code
T palldm Ab CSF IA-aCnc
Synonyms
T palldm Ab CSF IA-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for protein-related problems, such as low or high protein levels, which can affect how well your body heals, fights infections, or maintains fluid balance. It’s often used alongside other tests to diagnose conditions like kidney disease, liver disease, or malnutrition.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. If you’re fasting, follow your provider’s instructions. Avoid heavy meals or alcohol before the test.

What the Results Mean

Total protein combines albumin and globulin. Albumin helps keep fluids in your bloodstream, while globulins support immune function. Abnormal results may signal conditions like dehydration, liver disease, or chronic infections.

Common Conditions Linked to Protein Levels

Low protein levels (hypoproteinemia) can cause swelling, fatigue, or weakened immunity. High protein levels (hyperproteinemia) may indicate conditions like multiple myeloma or dehydration. Your provider will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein Profile in Health and Disease

Short name

Protein profile test

Frequently asked questions

How long will it take to get my results?
Results are typically available within 1–3 business days, depending on your lab. Your healthcare provider will discuss them with you during your follow-up visit.
Can I eat or drink anything before this test?
If fasting is required, avoid food and liquids (except water) for 8–12 hours before drawing blood. Check with your provider for specific instructions.
What if my protein levels are out of range?
If your results are abnormal, your provider may recommend further testing or treatments, such as dietary changes, hydration adjustments, or medications to address the underlying cause.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy