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Autoantibody Profile to Screen for Systemic Lupus Erythematosus (SLE) – Serum

Published: August 9, 2026Updated: August 16, 2026

This blood test checks for antibodies linked to systemic lupus erythematosus (SLE) or other autoimmune conditions. These antibodies may indicate inflammation or immune system dysfunction.

Quick summary

["This test helps doctors assess whether you may have an autoimmune disease like lupus or another condition affecting your immune system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46206-9
Short code
T palldm Ab Ser Donr Ql
Synonyms
T palldm Ab Ser Donr Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects several antibodies, including those that may target proteins in your joints, kidneys, blood cells, or skin. These antibodies can signal an overactive immune response, which is common in autoimmune diseases.

Why It Matters for Your Health

Finding these antibodies early can help doctors diagnose conditions like lupus, rheumatoid arthritis, or mixed connective tissue disease. It also guides treatment decisions to manage symptoms and prevent complications.

How the Test Works

A small blood sample is drawn, and the serum (liquid part of blood) is tested using immunoassay methods to identify specific antibodies. These methods detect the presence of antibodies that your immune system produces in response to normal body proteins.

Common Conditions This Test Helps Identify

This test is often used as a screening tool for autoimmune diseases. Positive results may prompt further testing to confirm a diagnosis or rule out other conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Lupus Antibody Panel (Screen)

Frequently asked questions

What does a positive or negative result mean?
A positive result for specific antibodies may indicate an autoimmune condition, but it doesn’t confirm a diagnosis alone. Your doctor will consider your symptoms, medical history, and other test results to make a full assessment.
Will I need more tests if this test is positive?
Yes, if your results suggest an autoimmune condition, your doctor may order additional tests, such as blood counts, kidney function tests, or imaging studies, to get a clearer picture of your health.
Can lifestyle changes affect these antibody levels?
While lifestyle factors like diet, stress, and exercise can influence overall health, they may not directly change antibody levels detected in this test. Always follow your doctor’s advice for managing symptoms and monitoring your condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy