Immunoassay for Anti-Drug Antibodies (e.g., to mAb1 or mAb2) in Serum/Plasma
This test checks for antibodies your body may form against certain medications, including monoclonal antibodies used in treatments like cancer or autoimmune diseases.
["Anti-drug antibodies can affect how well your medicine works or cause side effects."]
Key facts at a glance
- LOINC
- 5392-6
- Short code
- T palldm Ab Ser Immob-aCnc
- Synonyms
- T palldm Ab Ser Immob-aCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- immobilization
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you’re receiving a monoclonal antibody treatment (e.g., for cancer, rheumatoid arthritis, or other conditions) and want to monitor whether your body is developing antibodies against it. It helps ensure the medicine stays effective and reduces risks of complications.
What to Expect Before the Test
No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The blood sample is sent to a lab for testing. Results are typically ready within a few days.
What the Test Results Mean
If antibodies are found, it may mean your body is reacting to the medication differently than expected. This could impact your treatment plan. Your doctor will discuss results and next steps with you.
Possible Side Effects or Risks
The blood draw itself is usually safe but may cause mild discomfort or bruising. Rarely, antibodies can cause allergic reactions or affect how well the medicine works, but this is monitored closely during treatment.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Anti-drug antibodies can interfere with the intended effects of monoclonal antibody therapies. High levels may signal reduced drug efficacy, requiring dose adjustments or alternative treatments. Doctors use these results to tailor care and prevent complications like infections or immune-related side effects.
Short name
Anti-drug antibody screening
Frequently asked questions
What does a positive result mean?
Can I stop taking my medication if I have antibodies?
How often will I need this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy