Serum or plasma concentration of anti-double-stranded DNA antibodies (dsDNA antibodies)
This test measures the level of antibodies directed against double-stranded DNA, a component found in the nucleus of cells. It’s often used to help diagnose certain autoimmune conditions.
["This test helps assess for autoimmune diseases linked to DNA antibodies."]
Key facts at a glance
- LOINC
- 24312-1
- Short code
- T palldm Ab Ser Ql Aggl
- Synonyms
- T palldm Ab Ser Ql Aggl
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- aggl
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like joint pain, fatigue, or rash, or if you have a history of autoimmune diseases such as lupus (systemic lupus erythematosus). It may also be used to monitor disease activity in people already diagnosed with these conditions.
What to Expect Before the Test
No special preparation is needed for this blood test. You may have a small needle inserted into a vein in your arm to draw blood. If you’re on blood thinners, let your provider know before the test.
What the Test Results Mean
Elevated levels of anti-dsDNA antibodies are often associated with certain autoimmune diseases, particularly lupus. However, results alone don’t confirm a diagnosis. Your provider will consider your symptoms, medical history, and other test results together.
Common Conditions Linked to This Test
Anti-dsDNA antibodies are most strongly linked to systemic lupus erythematosus (lupus), though they can appear in other autoimmune conditions like Sjögren’s syndrome or certain types of rheumatoid arthritis. They may also be found in people without symptoms.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is primarily used as a marker to support a diagnosis of lupus or other autoimmune diseases. High levels can indicate disease activity and help guide treatment decisions. It’s not a definitive test alone but is often combined with other assessments, including physical exams and additional blood tests.
Short name
Anti-dsDNA Antibody
Frequently asked questions
What does a positive result mean?
Can this test be used to monitor lupus progression?
Are there any risks or side effects from this blood test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy