Serum or Plasma Immunoassay for Anti-Drug Antibodies (e.g., to Anti-Tumor Necrosis Factor Agents)
This test checks for antibodies your immune system may produce against medications used to treat conditions like rheumatoid arthritis, Crohn’s disease, or psoriasis.
["Helps determine if your body is reacting to certain disease-modifying drugs."]
Key facts at a glance
- LOINC
- 8041-6
- Short code
- T palldm Ab Ser Ql HA
- Synonyms
- T palldm Ab Ser Ql HA
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 1.5
- Ref high
- 9
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ha
- CPT
- 83002
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Some medications used to control autoimmune diseases (such as tumor necrosis factor inhibitors) can sometimes trigger an immune response that attacks the drug itself. This test detects whether your body has developed antibodies against these drugs, which could affect how well they work.
What to Expect Before the Test
No special preparation is needed. You’ll have a small needle inserted into your arm or vein to draw a blood sample. The test is usually done in a lab and results are ready within a few days.
Common Conditions This Test Helps Diagnose
This test is often used in patients on anti-tumor necrosis factor (TNF) therapy to monitor for antibody development, which may impact treatment effectiveness or cause side effects like infections.
What the Results Mean
Positive results indicate the presence of antibodies against the drug, which may require adjustments to your treatment plan. Negative results mean no antibodies were detected at this time.
Reference range
Follicular: 1.5-9.0 mIU/mLN/A
For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Antibodies against TNF inhibitors can reduce drug effectiveness, leading to less control over symptoms like joint pain or inflammation. They may also increase the risk of infections, as the drug’s anti-inflammatory effects are partially neutralized.
Short name
Anti-TNF Antibody Test
Frequently asked questions
Why might my doctor order this test?
What does a positive result mean for my treatment?
Can I still take the medication if my test is positive?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy