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Total Protein with Albumin-to-Globulin Ratio (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels and evaluates the balance between albumin and globulin proteins in your blood.

Quick summary

["Helps assess protein health and potential imbalances in your blood composition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107211-5
Short code
T palldm Ag Tiss Ql ImStn
Synonyms
T palldm Ag Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein includes both albumin and globulin proteins, which are vital for maintaining blood viscosity, immune function, and nutrient transport. Albumin is the most abundant protein, supporting fluid balance, while globulins include antibodies and other immune-related proteins.

How Is the Albumin-to-Globulin Ratio Used?

This ratio compares albumin (lowers with liver/kidney disease or malnutrition) to globulins (may rise with chronic inflammation or infection). An abnormal ratio can signal conditions like chronic liver disease, immune disorders, or malnutrition.

Why Might This Test Be Ordered?

Your doctor may request this test to diagnose or monitor conditions like chronic kidney disease, liver disease, malnutrition, or autoimmune disorders. It can also help evaluate protein-losing conditions or assess nutritional status.

Sample Preparation and Collection

A blood sample is drawn from a vein, typically in the arm. The sample is processed into serum (clotted blood) or plasma (anticoagulated blood) for testing. Avoid alcohol or strenuous activity 24 hours before testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein panel + Alb/Glob ratio

Frequently asked questions

What are the normal reference ranges for this test?
Reference ranges vary by lab and can’t be provided here. Your results will be interpreted by your healthcare provider based on your health status and other factors.
How long will it take to get my results?
Results are usually available within 1–3 business days, depending on your lab’s processing time. Follow-up with your doctor if you have questions or concerns.
Can I eat or drink before this test?
Fast for 8–12 hours before testing (no food or liquids except water), unless instructed otherwise by your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy