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Prostate-Specific Antigen (PSA) in Serum by Immunoassay (Screening Probe)

Published: August 9, 2026Updated: August 16, 2026

This blood test measures a protein produced by prostate cells, often used to check for early signs of prostate cancer or other prostate issues.

Quick summary

["PSA tests help monitor prostate health and guide follow-up care if abnormalities are detected."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53605-2
Short code
T palldm DNA Bld Ql NAA+probe
Synonyms
T palldm DNA Bld Ql NAA+probe
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is PSA Testing Used For?

PSA testing is primarily used as a screening tool to detect potential prostate problems. It can help identify whether further evaluation, such as a biopsy, is needed. However, PSA alone is not definitive for diagnosing prostate cancer and should be interpreted alongside clinical findings and patient history.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is then analyzed in a lab using an immunoassay method to measure PSA levels. This process is quick and typically requires no special preparation beyond fasting if instructed.

What Might Influence PSA Levels?

Several factors can affect PSA levels, including age, prostate inflammation (prostatitis), recent ejaculation, prostate surgery, or medical conditions like benign prostatic hyperplasia (BPH). It’s important to discuss any recent changes or conditions with your healthcare provider before testing.

When Might You Need This Test?

Your doctor may recommend PSA testing if you’re at higher risk for prostate cancer (e.g., age 50+ with average risk, age 45+ with higher risk factors like family history), or if you have symptoms like frequent urination, pain during urination, or blood in urine.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: PSA Levels and Prostate Health

Short name

PSA Screening

Frequently asked questions

Why do some people get repeated PSA tests?
Repeated PSA tests may be recommended if initial results are borderline or if you have symptoms or risk factors for prostate issues. Your doctor will use these results to guide whether further tests, like a digital rectal exam or biopsy, are needed to investigate further.
Can PSA levels be misleading?
Yes, PSA levels can be influenced by many factors, including age, prostate health, and recent activities like ejaculation. A single PSA test alone cannot definitively diagnose prostate cancer. Results should be reviewed by a healthcare provider who considers your full medical history and symptoms.
What if my PSA level is high?
A high PSA level may signal potential prostate issues, but it doesn’t always mean cancer. Your doctor will discuss next steps, which could include additional tests or follow-up appointments to determine the best course of action.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy