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Total Protein with Albumin-to-Globulin Ratio (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels in blood and evaluates the balance between albumin and globulin proteins, which are key to maintaining fluid balance and supporting immune function.

Quick summary

["Understanding your protein balance helps identify potential issues with kidney function, liver health, or immune system problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47512-9
Short code
T palldm IgG CSF-aCnc
Synonyms
T palldm IgG CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein includes both albumin and globulin proteins. Albumin helps regulate fluid distribution in your body, while globulins play a role in immune defense and transport of certain substances. Together, they reflect overall protein health in your bloodstream.

How Is Albumin-to-Globulin Ratio Used?

The ratio compares albumin (the smaller, more abundant protein) to globulins (which include antibodies and other proteins). A higher albumin-to-globulin ratio often suggests healthy protein distribution, whereas an imbalance may point to conditions like chronic inflammation, liver disease, or kidney problems.

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like swelling (edema), unexplained weight changes, fatigue, or signs of infection. It’s also used in monitoring conditions like kidney disease, liver disorders, or autoimmune diseases.

What Can Affect Test Results?

Factors such as dehydration, certain medications (e.g., steroids), recent infections, or dietary protein intake can influence protein levels. Blood collection timing (e.g., fasting) may also impact results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein profile test

Frequently asked questions

How long will I need to prepare for this test?
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if albumin is specifically measured. Avoid heavy meals or alcohol before drawing blood.
What are the normal ranges for this test?
Exact reference ranges vary by lab, but total protein is typically between 6.0–8.0 grams per deciliter (g/dL). The albumin-to-globulin ratio is often expressed as a ratio (e.g., 1.5:1) rather than absolute values, so results are interpreted relative to your individual health profile.
Can I take my usual medications before the test?
Yes, you can take your prescribed medications as usual, but inform your healthcare provider about any over-the-counter supplements or medications that might affect protein levels (e.g., NSAIDs, diuretics).
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy