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Total Protein with Albumin-to-Globulin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and evaluates the balance between albumin and globulin proteins, which can help assess kidney function, nutritional status, and immune response.

Quick summary

["Check protein balance and kidney health in one test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105193-7
Short code
T palldm IgG Index Ser+CSF-aCnc
Synonyms
T palldm IgG Index Ser+CSF-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein includes albumin and globulin, both vital for transporting nutrients, maintaining fluid balance, and supporting immune function. Albumin, produced by your liver, helps keep fluids in your bloodstream, while globulins, made by immune cells, assist in fighting infections and transporting substances like iron.

How Is the Albumin-to-Globulin Ratio Used?

A higher albumin-to-globulin ratio often suggests good liver function and adequate protein intake, while a lower ratio may indicate liver disease, malnutrition, or chronic inflammation. This ratio can also help identify kidney problems, such as proteinuria, where the kidneys lose too much protein in urine.

Why Might This Test Be Ordered?

Your healthcare provider may order this test to evaluate kidney function, diagnose liver disease, check for malnutrition, or monitor conditions like chronic kidney disease, autoimmune disorders, or infections.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein & AG Ratio

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–2 business days, depending on your lab. Follow-up with your provider to discuss any findings.
Can diet affect this test?
Yes, high-protein diets or certain medications (like steroids) may influence protein levels. Avoid extreme dietary changes before testing to get accurate results.
What if my results are out of range?
Your provider will explain what the results mean in the context of your health. Abnormal findings may prompt further tests or treatments to address underlying issues.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy