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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum, which helps assess overall protein status and kidney function.

Quick summary

["Your blood protein levels can signal kidney health or nutritional needs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110930-5
Short code
T palldm IgG Msmt CSF
Synonyms
T palldm IgG Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Matters

Blood proteins, including albumin and globulins, play key roles in maintaining fluid balance, supporting immunity, and transporting nutrients. Low levels may indicate kidney disease, malnutrition, or liver issues, while high levels could suggest dehydration or certain medical conditions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners or have a history of clotting issues, let your provider know.

Common Causes of Abnormal Results

Elevated protein levels might be due to dehydration, multiple myeloma, or severe infections. Low levels could stem from kidney disease, liver problems, or poor nutrition. Always discuss results with your healthcare team.

When This Test Might Be Ordered

Your doctor may request this test to check for kidney function, monitor chronic conditions like liver disease or heart failure, or evaluate nutritional health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels are a general marker of protein synthesis and breakdown. While albumin is the most abundant protein, measuring total protein helps identify systemic imbalances that may not be detected by individual protein tests alone. Abnormal results often prompt further investigation into underlying causes, such as organ dysfunction or metabolic disorders.

Short name

Total Protein

Frequently asked questions

What does a ‘total protein’ test measure?
This test measures the combined weight of all proteins in your blood serum, including albumin, globulins, and other proteins like fibrinogen. It’s not a specific test for any single protein but provides an overall picture of protein status.
How is the blood drawn for this test?
A healthcare professional will insert a small needle into your arm to collect blood into a tube. The process usually takes a few minutes and may cause a brief pinch or discomfort. You can drink water afterward to help with any mild bruising.
Can diet affect my total protein test results?
Dietary protein intake may influence short-term protein levels, but total protein tests are generally stable over a few days. Avoid extreme dietary changes before the test, but no special diet is required unless instructed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy